Summary/Abstract: Aft er establishment of administration in newly acquired provinces at southeast of Europe, because of frequent plague epidemics Habsburg Monarchy formed a sanitary safety belt at the border with Ottoman Empire. Th is paper will describe measures taken at Paraćin quarantine that, in the period 1718–1739 used to be one of the busiest. Organization of the quarantine, procedures and instructions sent by Royal court commission were aimed at preventive actions to protect population health.