Accidental medicament hypertension

Nebojša, Božinović, Dragica

Glasnik Antropološkog društva Jugoslavije

39

173

178

0351-1480

http://scindeks.ceon.rs/article.aspx?query=ISSID%26and%263559&page=0&sor...

2004-2021/11/05/09:41:25

The last decade of 20th century and the first years of 21st century developed a long range of new illnesses on the medicine scene, which were unknown to the classic medicine ( Lyme disease, Sy.Kawasaki, HIV,SARS). none of these diseases have not presented isolated. They have appeared together with one or even two or three parallel syndromes. Such polymorph clinical pictures need multidimensional therapy approach. Some of the medicaments used in this occasion could cause arterial hypertension. At the top list of incriminated medicaments which are met nowadays are: unsteroid antirheumatics corticosteroids and some hormones such as eritropoetin, ciklosporin from a group of imunosuppressors medicaments. Unsteroids antirheumathics change the quality of the blood are assure by inhibition of prostaglandin production. They even change the whole volume of circulated blood and the whole electrolyte balance. Our researches have shown that medicaments out of this group: Aspirin, Diclofen, Brufen, Naproksen, Roxicam, significantly decrease antihypertensive effects of diuretics, beta - blocators and prazosin, while their hypertensive potential are presented by increased blood pressure approximately 10 mm Hg. Corticosteroids and eritropoetin lead to increased blood pressure. It mainly appears to patients who have hypertension, diabetes or kidney illness. eritropoetin increases blood pressure directly and indirectly: by increasing of hematocrit and viscosity of blood, which results with increased of peripheral vascular resistance and again with hypertension. Imunosuppressive medicaments and ciklosporin, frequently lead to hypertension and their effects are speculating.