This study presents possibilities for evaluation of radiation lesions induced by exposure to radionuclide. Genetic monitoring was conducted by cytochalasin-block (CB) micronucleus test in subjects working with open source of radiation (nuclear medicine). The study comprised two groups of subjects: 23 individuals that worked in once nuclear medicine center (the first group) and 11 individuals that worked in the other nuclear medicine center (the second group). Analysis of controls were those free from exposure to mutagenic agents (23 individuals). Comparison of the exposed and control groups revealed significant difference (p<0,05) between them. The changes in the genetic material of occupationally exposed subjects, can be correlated with exposure to ionizing radiation, inadequate occupational protection, poor education and individual sensitivity to radiation.
