Dominant laterality de notes appearance of a dominant extremity or sense in the performance of complex psychomotor activities. The aim of this study was to investigate the dominant side and hand preference by means of various manual procedures. This investigation was concerned with sex interaction, dominant sides and ethnic affiliation. The sample consisted of 200 Albanian and 200 Macedonian students of both sexes, aged between 15-19 years, randomly chosen and examined. Measure of hand preference for 12 different activities was obtained by using (Briggs and Nebes 1975). modification of the original Annett-s hand preference questionnaire. Sex was not significantly related to handedness in both examined groups. In Albanian individuals from R. Macedonia (both sexes) the distribution of left-handedness was 5,2 %, and in the sample of Macedonian population 8,8 %. It was found that a family history of left handedness was significantly related to the handedness of the all subjects. Our results were compared with earlier studies and similarity was found with other European populations.