Analysis of antigens of HLA system, i.e. research of polymorphism of I and II class of HLA antigens, was conducted in the Vojvodina Institute for Blood Transfusion in Novi Sad, with unrelated persons from different parts of Vojvodina, with the aim to find compatible donors for tissue and organ transplantation and establishing parenthood in disputable cases. The researched was conducted on a sample of 350 unrelated persons phenotyped for HLA-A and HLA-B alleles and 174 unrelated persons phenotyped for HLA-DR and HLA-DQ alleles. Methods used for determining classes I and II of HLA antigens were the microlymphocytotoxicity test by Terassaki and the bicolor immunofluorescence method. The obtained results show that there exist differences in the frequency of certain HLA alleles in the population of Vojvodina, compared to the population of Europe, as well as specific variations compared to the population of Serbia, which points at the specificity of the population of Vojvodina, which is probably influenced among other things by a great number of nations, nationalities and ethnicities living in that area. .
