Medieval necropolis at the porch of St.Pantejmon church in Nis, from 12th century represents a typical Serbian necropolis which has its analogies in several areas in Serbia. Preservance of skeletal remains belongs to category of well and medium perseverance. The aim was to analyze the prevalence of caries on teeth, according to sex and localization of carious lesions, according to primary and secondary retentional places. The analyses included 30 skeletal remains. Anthropological analyses involved paleopathological finding on786 teeth of 15 men and 15 women. Tooth caries was determined by inspection, dental probe, dental mirror and radiology. Epidemiological researches were realized by caries index average (KIa). Antropological teeth caries localization research of osteological material from medieval locality of St. Pantelejmon church in Nis showed a presence of caries with 7,63% cases, more in women (9,76) than men (5,65). Caries was localized in most cases on secondary retentional places (80%).