The association between the presence of diagonal earlobe crease (ELC) and coronary artery disease (CAD) was first reported by Fank 1973 (positive ear lobe sign). This connection still remains controversial. The aim of this study was to evaluate the association between bilateral ELC, preauricular creases (PAC) to CAD and other coronary risk factors. A total of 150 patients were examined (aged 30-80) grouped by age and sex .70 of them were diagnosed with CAD. The control group included 80 patients (asymptomatic) with normal ECG. Bilateral ELC and preauricular creases were significantly and positively correlated with CAD, hypertension, age(>40), male gender and cigarette smoking. Positive predictive value of the ELC and PAC for CAD was 60%. The bilateral ELC and PAC were an important dermatological indicators of CAD and they might be a useful diagnostic tool in clinical examination of patients. .
