The purpose of this paper is to describe the influence of the disease and its consequences on health-related quality of life through some physical components. The study included 122 patients who suffered from viral and bacterial CNS infections and were treated at Infectious Diseases Clinic in Novi Sad. The patients were separated into two groups: cured and cured with sequelae. The data about the course and the outcome of the disease were provided from the history of the disease. SF-36 questionnaire (The MOS 36-Item Short-Form Health Survey) was used for the quality of life assessment. The survey was undertaken 6 months and 12 months after the appearance of acute disease. Initial results showed that 65,7% of cured patients with sequelae had serious difficulties with physical functioning; 74,3% of them had physical health limitations and more than a half of the patients in this group described their general health status as poor with worsening tendencies. Less than one-third in the group of cured patients had limitations of everyday activities, and almost half of them described their general health status as poor. The final results revealed that serious difficulties with physical functioning persisted in 45,7 % of cured patients with sequelae, 54,3% of them had poor physical health and one-fifth of them had poor general health status. In the group of cured patients, only 11,9% of them s20 had some limitations of everyday activities, every sixth patient had difficulties with physical functioning and every eighth patient in this group described his/her general health status as poor. The research results show the significance of the new concept of sickness and health which purpose is to discover and suppress causes of a disease as early as possible as well as impede disease development and its consequences by preventive measures and thus enhance and preserve people's health.
