Osteoporosis could cause the significant changes of bone structure. Severe changes should be expected in temporo-mandibular joint (TMJ) due to osteoporotic negative remodeling. The aim of this study was to determine changes and shape and form of temporo-mandibutar joint surtace of partially edentulous and completely edentulous osteoporotic patients. On the basis of decreased bone density and panoramic radiographs of patients, 73 (23 men, aged 61-75 yrs., and 50 women, aged 59-76 yrs.) were selected for this experiment. Panoramic radiographs were provided for each of the patient of the experimental group (Orthopantomograph 10-serial number 01492, Siemens, Germany). In relation to contour of bony surfaces of TMJ, as well as lines assigned, deviations of intercondylar axis and mandibula-basal lines to reference hortzontal and saggital planes, and change of surfaces of temporo-mandibutar joint were assessed. Low values of bone density, reductions of dimension of condylar surface of an one or the both of temporo-mandibul ar joint condyles as well as temporo-mandibular joint surfaces, deviation of position of intercondylar axis and negative remodeling were established. Orofacial dysfunction's can be provoked in osteoporotic subjects as a consequence of reduction of bone layer's density in jaw-bone and negative remodeling.