The aim of the research was to determine the variations in the shape and morphology of upper premolars. The research was carried out on 624 study models (313 male, 311 female) for P1 and 594 (294 male and 300 female) for P2 orthodontic patients on the Dental Clinic in Niš. Zubov's methodology was used. Upper first and second premolar crown morphology was determined based on the degree of development of buccal and palatinal cusps (three types). The shape of the occlusal plane was also analyzed (triangular, oval and renal). Presence of different shape types of upper P1 crowns is the following: in patients of both sexes type 2 dominates (71.73% in males and 76.05% in females). It is similar in P2. In both sexes, the most dominant is type 2 (73.13% in males and 55.5% in females). The triangular shape of upper P2 is the most numerous in people of both sexes (89.03% in boys and 81.02 in girls). Upper P2 in male patients are mostly of triangular shape (51.87%) while in female patients triangular and oval shapes are present in almost the same percentage (49.83% oval shape and 49.16% triangular shape).