The research purpose is to search for some connection between blood type systems ABO and Rhesus factor and Ca vulvae. A study was conducted 97 women with carcinoma vulvae. The results of the blood type system ABO are compared to those of Bulgarian population (Todorov 1998-1999). There is a higher frequency of type O among those patients (p < 0,05). The data compared within palient's group show the same significant results - a higher frequency of type O in comparison with A, (p < 0,05). The authors suppose perhaps there is a connect ion between blood type and cancerogenesis (according to some authors such is find among patients with carcinoma and blood groups). .