Analysis of the polymorphism -590 C/T of IL-4 gene in Bosnian-Herzegovinian population
Amela, Hercegovac, Rifet, Terzić, Snježana, Hodžić, Aldijana, Tursunović, Danijel, Petrovič
Glasnik Antropološkog društva Srbije
48
115
120
1820-7936
10.5937/gads1348115H
http://scindeks.ceon.rs/article.aspx?query=ISSID%26and%2612263&page=0&so...
2013-2021/11/03/10:58:33
One from a number of problems that occur when attempting to establish a possible link between certain diseases and genetic polymorphisms is certainly the absence of data on the frequency of these polymorphisms in general populations. Any variation in allele frequencies between different populations may have clinical significance. Factors that may influence the association of alleles with disease, such as ethnic or gender effect, is not possible to determine without allele frequencies in the general population. Aim of the research was to analyze the polymorphism -590 C/T of IL-4 gene in general bosnian-herzegovinian population. From a total of 528 patients analyzed for the polymorphism of IL-4 -590 C/T, 22 had the TT genotype, 150 TC and 356 CC genotype. Genotyping was performed by PCR - RFLP method. Comparing the frequencies of genotypes by gender did not determine statistically significant difference. The distribution of genotypes in the total sample was consistent with Hardy-Wainberg's equilibrium (p = 0.2251). Analysis of the -590 C/T polymorphism determined the allele frequencies T 0.18 and C 0.82 in the total sample. Comparing the allele frequency with the frequencies determined in other European general populations found no statistically significant difference. Further investigations that would be in relation to the association of certain genotypes and specific immune phenomena would be important for explaining the basic biological processes and indicating ways of prediction, prevention or repair of adverse situations in immunological diseases.