Excretion of 17-ketosteroids in adult and aged people

Kr, Vizev

Glasnik Antropološkog društva Jugoslavije

34

117

121

0351-1480

https://scindeks.ceon.rs/article.aspx?query=ISSID%26and%263567&page=0&so...

1998-2021/11/03/12:18:02

The function of the suprarenal cortex was investigated in advanced (60-74 years), senile (75-9 years) and long-lived (90+years) age, in total of 126 individuals, by means of the excretion of 17-ketosteroids in 24 hour urine as the principal metamolite of plasma cortisol. The method of Zimmerman reaction with chromatographic colorimetry was used. The analysis of the obtained data revealed that the glucocorticoid function with advance of the age slightly modified and was preserved at a comparatively high level including in the long-lived individuals, too. The clinical observations also confirmed the standpoint, that the glucocorticoid function with advance of the age insignificantly decreased and the presented values were directly dependent of the functional capacities of the suprarenal glands in both sexes, too. In advanced age (60-74 years) the author denoted gradual uniform decrease of the twenty-four-hour excretion of 17-KS (29.05 mkmol/24 hours ù up to 26.45 mkmol/l for 24 hours). The transition from advanced to senile age was markedly expressed by diminution of the values of 17-KS, the difference between advanced (60-74 years) and long-lived age (90+years) was highly significant in both sexes, too (p<0.001). Conclusion is made that the presented values of the 17-KS in advanced and senile ages could serve as objective criterion (rates, norms) in the general complex of functional morphologic and metabolic features of the body, which occur in senility. Particular significance they assume in determination of the biologic age of man.