Genetic alterations of tumor suppressor gene in sporadic colorectal cancers

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Hadžiavdić, V., Eminović, I., Hamidović, H., & Pavlović-Čalić, N. (2012). Genetic alterations of tumor suppressor gene in sporadic colorectal cancers, (47), 155-162. doi:10.5937/gads1247155H
Details
Title

Genetic alterations of tumor suppressor gene in sporadic colorectal cancers

Subtitle
Author

Vesna, Hadžiavdić, Izet, Eminović, Hajrija, Hamidović, Nada, Pavlović-Čalić

Journal

Glasnik Antropološkog društva Srbije

Volume
Issue

47

Start page

155

End page

162

ISSN

1820-7936

ISBN
DOI

10.5937/gads1247155H

URL

http://scindeks.ceon.rs/article.aspx?query=ISSID%26and%2610225&page=0&so...

Date

2012-2021/11/03/10:47:48

Abstract

Colorectal cancer with its frequency, high mortality rate as well as many etiological unknowns is a challenge to contemporary science. Finally, genetic information could be used in near future for prevention of colorectal cancer, its early diagnosis and selection for the most suitable hospital treatment. In this study, we analysed genetic alterations of tumor suppressor genes and the possibility of quick and efficient screening method for identification of colorectal cancer. The study consisted of 54 samples of tumor and surrounding healthy tissue of patients with colorectal cancer, which is clasificated according to Bethesda and Amsterdams criterias. The investigation showed that genetic alterations of tumor suppressor gene NM 23 were present in 19/35 (54,29%) samples, and tumor suppressor gene p53 in 18/35 (51,43%), APC in 18/35 (51,43%), DCC2 tumor suppressor gene in 12/35 (34,29%), tumor suppressor gene RB1 in 8 /35 (22, 86%) and DCC 1 in 10/35 ( 28,57%) tumor tissue.

Keywords